Searchable abstracts of presentations at key conferences in endocrinology

ea0099oc8.2 | Oral Communications 8: Thyroid | ECE2024

Antigen-specific peptide immunotherapy attenuates the pathogenic response in a murine model of Graves’ disease

Cho Yi-Li , Wenhart Clara , Gobel Silvia , Reimann Andreas , Li Zhongmin , Munch Gotz

Background: GravesÂ’ disease (GD) is an autoimmune disease caused by autoantibody targeting the thyrotropin receptor (TSHR) in the thyroid gland, resulting in hyperthyroidism with an annual incidence of 15 to 80/100,000 people worldwide. Current mainstream treatments for GD include aggressive treatment with radioiodine and thyroidectomy or unspecific immune-modulating therapy with glucocorticoids, antithyroid medications or anti-CD20 antibodies like Rituximab. Therefore, o...